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Hypogonadotropic hypogonadism Generics
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Hypogonadotropic hypogonadism - Generics

Hypogonadotropic hypogonadism (HH) is a medical condition characterized by low levels of sex hormones due to a disruption in the normal functioning of the hypothalamus or pituitary gland, which regulate the production of these hormones.

HH can occur as a result of genetic factors, brain tumors, head injuries, infections, or certain medications. It can also be a secondary effect of other medical conditions, such as chronic kidney disease, liver disease, or malnutrition.

Symptoms of HH can include delayed or absent puberty, infertility, low libido, erectile dysfunction, decreased muscle mass, and decreased bone density. In women, HH can also cause irregular menstrual cycles or a complete lack of periods.

Diagnosis of HH involves blood tests to measure levels of sex hormones and other hormones involved in their regulation. Imaging studies, such as MRI or CT scans, may also be used to identify any structural abnormalities in the brain that may be contributing to the condition.

Treatment of HH typically involves hormone replacement therapy, which involves administering synthetic versions of the missing hormones. In men, this may involve testosterone replacement therapy, while in women, it may involve estrogen and progesterone replacement therapy.

In some cases, treatment of the underlying condition causing HH may also be necessary to address the hormonal imbalances. Counselling or therapy may also be recommended to address any psychological or emotional issues related to the condition, such as infertility or sexual dysfunction.


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