POEMS syndrome is a rare disorder that affects multiple parts of the body, including the nervous system, skin, and blood vessels. The name POEMS stands for several of the common symptoms of the condition: polyneuropathy, organomegaly (enlargement of organs), endocrinopathy (hormone imbalances), M-protein (an abnormal antibody in the blood), and skin changes.

Symptoms of POEMS syndrome may include weakness, numbness or tingling in the arms and legs, enlarged liver or spleen, swollen lymph nodes, swollen legs or ankles, hormonal imbalances, changes in skin color or texture, and difficulty breathing.

The exact cause of POEMS syndrome is unknown, but it is believed to be related to overproduction of certain proteins by plasma cells in the bone marrow. This can lead to damage to the nerves, blood vessels, and organs.

Treatment for POEMS syndrome may involve medications to reduce the production of abnormal proteins and manage symptoms such as pain and swelling. In some cases, treatment may also involve chemotherapy, radiation therapy, or stem cell transplantation. Supportive care, such as physical therapy, occupational therapy, and pain management, can also be helpful for managing symptoms and improving quality of life.

POEMS syndrome is a rare condition and may be difficult to diagnose. If you are experiencing symptoms that are consistent with POEMS syndrome, it is important to seek medical attention from a healthcare provider who is familiar with the condition. A diagnosis may involve a combination of medical tests and examinations, including blood tests, imaging studies, and nerve conduction studies.